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Voltammetric Studies of Propylthiouracil at a Carbon-Paste Electrode Modified with Cobalt(II)-4-chlorosalophen: Application to Voltammetric Determination in Pharmaceutical and Clinical Preparations

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Abstract.

A carbon-paste electrode chemically modified with a Schiff-base complex of cobalt (cobalt(II)-4-chlorosalophen, CoClSal) is utilized to investigate the voltammetric response of propylthiouracil (PTU). The mechanism of electrocatalytic oxidation of the compound is investigated by means of cyclic voltammetric studies applying various pHs to the buffered solutions. The modified electrode exhibits effective catalytic properties that lower the anodic overpotential and enhance the rate of electron transfer for the electrochemical oxidation of PTU. The results of the cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques showed that the modified electrode exhibits good selectivity for discriminating between the anodic wave of PTU and some biological thiols (e.g. cysteine) which may be present in human serum samples. DPV is used as a very sensitive electroanalytical method for the detection of trace amounts of PTU in pharmaceutical and clinical preparations. The results showed that the anodic peak current for the analyte in DPV varies linearly with the concentration of PTU in the range of 7.5 × 10−6 to 7.5 × 10−4 M (RSD for the slope of calibration curve <4%, n = 6).

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References

  • M Wrona B Czochralska D Shugar (1976) J Electroanal Chem 68 355 Occurrence Handle10.1016/0368-1874(76)80128-1

    Article  Google Scholar 

  • J Carbon H David M H Studier (1968) Science 161 1146

    Google Scholar 

  • M N Lippsett (1965) J Biol Chem 240 3975 Occurrence Handle5320644

    PubMed  Google Scholar 

  • J A Nelson J W Carpenter M L Rose D Adamson (1975) J Cancer Res 35 872

    Google Scholar 

  • S Shigeta S Mori T Kira K Takahashi E Kodama K Konno T Nagata H Kato T Wal N Koike M Saneyoshi (1999) Antivirial Chem Chemother 10 195

    Google Scholar 

  • http://www.medicinenet.com/propylthiouracil/article.htm

  • http://monographs.iarc.fr/htdocs/monographs/vol79/79-03.html

  • S von Schmideberg U Hanten C Goebel H C Schuppe J Uetrecgt E Gleichmann (1996) Clin Immunol Immunopathl 80 162 Occurrence Handle10.1006/clin.1996.0110

    Article  Google Scholar 

  • http://ehp.niehs.nih.gov/roc/tenth/profiles/s156prop

  • C R Ratliff P F Gilliard F F Hall (1972) Clin Chem 18 1373 Occurrence Handle4652835

    PubMed  Google Scholar 

  • D S Sitar B D Hunninghake (1975) J Clin Endocrinol Metab 40 26 Occurrence Handle1112878

    PubMed  Google Scholar 

  • R K Buick C Barry I M Traynor W J McCaughey C T Elliott (1998) J Chromatogr B 750 71

    Google Scholar 

  • C G Duarte A C M Polizello A I Assis-Pandochi A C C Spadaro (2000) J Pharm Biomed Anal 23 237 Occurrence Handle10.1016/S0731-7085(00)00275-2 Occurrence Handle10898176

    Article  PubMed  Google Scholar 

  • W Ciesielski R Zakrzewski (1997) Analyst 122 491 Occurrence Handle10.1039/a700137a Occurrence Handle9246819

    Article  PubMed  Google Scholar 

  • S Komorsky-Lovric V Mirceski F Scholz (1999) Microchim Acta 132 67

    Google Scholar 

  • G Zhiqiang S S Kok A Ng Z Yimin (1997) Anal Chim Acta 343 49 Occurrence Handle10.1016/S0003-2670(96)00605-8

    Article  Google Scholar 

  • K Kalcher J M Kaufmann J Wang I Svancara K Vytras C Neuhold Z Yang (1995) Electroanalysis 7 5 Occurrence Handle10.1002/elan.1140070103

    Article  Google Scholar 

  • J L Anderson E F Bowden P G Pickup (1996) Anal Chem 68 379R Occurrence Handle10.1021/a1960015y

    Article  Google Scholar 

  • H A O Hill (1996) Coord Chem Rev 151 115

    Google Scholar 

  • S A Wring J P Hart (1992) Analyst 117 1215 Occurrence Handle10.1039/an9921701215

    Article  Google Scholar 

  • T Inoue J R Kirchhoff (2000) Anal Chem 72 5755 Occurrence Handle10.1021/ac000716c Occurrence Handle11128932

    Article  PubMed  Google Scholar 

  • B Ortiz S I Mho D Ingersoll N Doddapaneni M S Park (1995) J Electrochem Soc 142 1436

    Google Scholar 

  • M A Ruiz M G Blazquez J M Pingarron (1995) Anal Chim Acta 305 49 Occurrence Handle10.1016/0003-2670(94)00340-R

    Article  Google Scholar 

  • F Xu H Li S J Cross T F Guarr (1994) J Electroanal Chem 368 221 Occurrence Handle10.1016/0022-0728(93)03102-U

    Article  Google Scholar 

  • S Shahrokhian J Yazdani (2003) Electrochim Acta 48 4143 Occurrence Handle10.1016/S0013-4686(03)00582-6

    Article  Google Scholar 

  • M K Amini S Shahrokhian S Tangestaninejad V Mirkhani (2001) Anal Biochem 290 277 Occurrence Handle10.1006/abio.2000.4929 Occurrence Handle11237330

    Article  PubMed  Google Scholar 

  • S Shahrokhian M K Amini I Mohammadpoor-Baltork S Tangestaninejad (2000) Electroanalysis 12 863 Occurrence Handle10.1002/1521-4109(200007)12:11<863::AID-ELAN863>3.0.CO;2-H

    Article  Google Scholar 

  • R S Martin A J Gawron B A Fogarty F B Regan E Dempsey S M Lunte (2001) Analyst 126 277 Occurrence Handle10.1039/b009827m Occurrence Handle11284324

    Article  PubMed  Google Scholar 

  • G Favaro M Fiorani (1996) Anal Chim Acta 332 249 Occurrence Handle10.1016/0003-2670(96)00265-6

    Article  Google Scholar 

  • M S Aguirre M Isaacs F Armijo N Bocchi J H Zagal (1998) Electroanalysis 10 571 Occurrence Handle10.1002/(SICI)1521-4109(199807)10:8<571::AID-ELAN571>3.0.CO;2-7

    Article  Google Scholar 

  • M K Halbert R P Baldwin (1985) Anal Chem 57 591 Occurrence Handle10.1021/ac00280a007

    Article  Google Scholar 

  • X Qi R P Baldwin (1996) J Electrochem Soc 143 1283

    Google Scholar 

  • J Wang T Golden (1989) Anal Chim Acta 217 343 Occurrence Handle10.1016/S0003-2670(00)80416-X

    Article  Google Scholar 

  • Y H Tse P Janda A B P Lever (1994) Anal Chem 66 384 Occurrence Handle10.1021/ac00075a012

    Article  Google Scholar 

  • P Janda J Weber L Dunsch A B P Lever (1996) Anal Chem 68 960 Occurrence Handle10.1021/ac950323r

    Article  Google Scholar 

  • M K Amini J H Khorasani S S Khaloo S Tangestaninejad (2003) Anal Biochem 320 32 Occurrence Handle10.1016/S0003-2697(03)00355-5 Occurrence Handle12895467

    Article  PubMed  Google Scholar 

  • S Shahrokhian A Souri H Khajehsharifi (2004) J Electroanal Chem 565 95 Occurrence Handle10.1016/j.jelechem.2003.09.039

    Article  Google Scholar 

  • G Shi J Liu F Xu W Sun L Jin K Yamamoto S Tao J Jin (1999) Anal Chim Acta 391 307 Occurrence Handle10.1016/S0003-2670(99)00274-3

    Article  Google Scholar 

  • H Li T Li E Wang (1995) Talanta 42 885 Occurrence Handle10.1016/0039-9140(95)01502-3

    Article  Google Scholar 

  • T J Mafatle T Nyokong (1996) J Electroanal Chem 408 213 Occurrence Handle10.1016/0022-0728(95)04519-8

    Article  Google Scholar 

  • B Nalini S S Narayanan (1998) Electroanalysis 10 779 Occurrence Handle10.1002/(SICI)1521-4109(199809)10:11<779::AID-ELAN779>3.0.CO;2-U

    Article  Google Scholar 

  • Y H Tse P Janda H Lam A B P Lever (1995) Anal Chem 67 981 Occurrence Handle10.1021/ac00101a028

    Article  Google Scholar 

  • J P Hart I C Hartley (1994) Analyst 119 259 Occurrence Handle10.1039/an9941900259

    Article  Google Scholar 

  • D A Atwood J A Jegier D Rutherford (1996) Inorg Chem 35 63 Occurrence Handle10.1021/ic950574i Occurrence Handle11666165

    Article  PubMed  Google Scholar 

  • S Shahrokhian M K Amini R Kia S Tangestaninejad (2000) Anal Chem 72 956 Occurrence Handle10.1021/ac990749w Occurrence Handle10739198

    Article  PubMed  Google Scholar 

  • Bard A J, Faulkner L L (2001) Electrochemical methods, fundamentals and applications, 2nd edn. Wiley, New York

  • S Shahrokhian A Hamzeloei A Taghani S R Mousavi (2004) Electroanalysis 16 915 Occurrence Handle10.1002/elan.200302858

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Chemistry, Sharif University of Technology, 11365-9516, Tehran, Iran

    Saeed Shahrokhian & Mohammad Jalal Jannat-Rezvani

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  1. Saeed Shahrokhian
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  2. Mohammad Jalal Jannat-Rezvani
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Correspondence to Saeed Shahrokhian.

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Shahrokhian, S., Jannat-Rezvani, M. Voltammetric Studies of Propylthiouracil at a Carbon-Paste Electrode Modified with Cobalt(II)-4-chlorosalophen: Application to Voltammetric Determination in Pharmaceutical and Clinical Preparations. Microchim Acta 151, 73–79 (2005). https://doi.org/10.1007/s00604-005-0382-z

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